m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition
نویسندگان
چکیده
منابع مشابه
I-52: Maternal mRNA Metabolism duringOocyte-to-Zygote Transition
Background: Maternal mRNA degradation is a selective process that occurs in waves corresponding to important developmental transitions such as resumption of meiosis, fertilization and zygotic genome activation. It has been demonstrated that the number, position, and combination of 3 UTR cis-acting elements interacting with trans-acting protein factors regulate translation and mRNA stability. Ou...
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To gain a better understanding of the molecular differences that may contribute to cleavage arrest and the poorer development associated with laboratory produced embryos, a series of experiments were conducted to quantitate the message levels of the cell cycle controller cdc25c, over the maternal to zygotic transition (MZT) in 4-cell in vivo- and in vitro-derived porcine embryos. The experiment...
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The handover from maternal to zygotic control has to be carefully orchestrated. In most animal embryos, maternal products drive early embryogenesis, and the genome of the zygote is only switched on later. However, in the nematode Ascaris the zygotic genome is never silent, and the maternal products are rapidly eliminated.
متن کاملThe maternal-to-zygotic transition: a play in two acts.
All animal embryos pass through a stage during which developmental control is handed from maternally provided gene products to those synthesized from the zygotic genome. This maternal-to-zygotic transition (MZT) has been extensively studied in model organisms, including echinoderms, nematodes, insects, fish, amphibians and mammals. In all cases, the MZT can be subdivided into two interrelated p...
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Early steps of embryo development are directed by maternal gene products and trace levels of zygotic gene activity in vertebrates. A major activation of zygotic transcription occurs together with degradation of maternal mRNAs during the midblastula transition in several vertebrate systems. How these processes are regulated in preparation for the onset of differentiation in the vertebrate embryo...
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ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature21355